Preprint (JMIR Preprints): https://preprints.jmir.org/preprint/31269
Authors' Response to Peer-Review Reports: https://med.jmirx.org/2022/1/e36212/
Published Article: https://med.jmirx.org/2022/1/e31269/
This is a peer-review report submitted for the paper “Measuring Integrated Novel Dimensions in Neurodevelopmental and Stress-Related Mental Disorders (MIND-SET): Protocol for a Cross-sectional Comorbidity Study From a Research Domain Criteria Perspective.”
Round 1 Review
This paper  is interesting and sets the stage for a pretty comprehensive study.
- The background is very long, and some spaces are redundant, talking about the overlap of symptoms in comorbidities. Some of this may be better in a discussion—there is a lot of information here.
- There are a lot of definitive/overly positive statements (eg, “...the RDoC [Research Domain Criteria] frameworks fits ideally...” “...we can disentangle.” Consider rewording as this is a fairly small sample size in a singular area of the world.
- Adjust the title so it is clear that this is a description of methods.
- Anticipated limitations should be included (eg, single-center, nondiverse population, or the number of data points making differentiation challenging).
- Change addiction disorder to substance use disorder
- Provide a citation for the first line about the acceptance of psychiatric comorbidities as common
- Define abbreviations upon first use (eg, DSM-5)
- Consider changing “healthy” to “neurotypical.” Personality traits were examined too, but there is not a lot of rationale here regarding overlap. I agree it is important to review this too, but this needs to be discussed.
- Is microbiome included at the very end as a data point?
Round 2 Review
It appears that the recommended revisions have been addressed, and I have no additional comments
Conflicts of Interest
- van Eijndhoven P, Collard R, Vrijsen J, Geurts DE, Vasquez AA, Schellekens A, et al. Measuring Integrated Novel Dimensions in Neurodevelopmental and Stress-Related Mental Disorders (MIND-SET): protocol for a cross-sectional comorbidity study from a Research Domain Criteria perspective. JMIRx Med 2022;3(1):e31269 [FREE Full text]
|RDoC: Research Domain Criteria|
Edited by E Meinert; This is a non–peer-reviewed article. submitted 06.01.22; accepted 06.01.22; published 29.03.22Copyright
©Emma Palmer. Originally published in JMIRx Med (https://med.jmirx.org), 29.03.2022.
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