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The background is very long, and some spaces are redundant, talking about the overlap of symptoms in comorbidities. Some of this may be better in a discussion—there is a lot of information here.
There are a lot of definitive/overly positive statements (eg, “...the RDoC [Research Domain Criteria] frameworks fits ideally...” “...we can disentangle.” Consider rewording as this is a fairly small sample size in a singular area of the world.
Adjust the title so it is clear that this is a description of methods.
Anticipated limitations should be included (eg, single-center, nondiverse population, or the number of data points making differentiation challenging).
Change addiction disorder to substance use disorder
Provide a citation for the first line about the acceptance of psychiatric comorbidities as common
Define abbreviations upon first use (eg, DSM-5)
Consider changing “healthy” to “neurotypical.” Personality traits were examined too, but there is not a lot of rationale here regarding overlap. I agree it is important to review this too, but this needs to be discussed.
Is microbiome included at the very end as a data point?
It appears that the recommended revisions have been addressed, and I have no additional comments
None declared.
Research Domain Criteria