Search Articles

View query in Help articles search

Search Results (1 to 10 of 11 Results)

Download search results: CSV END BibTex RIS


Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis

Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis

Whether or not cancer develops in response to EBV infection depends on major histocompatibility complex (MHC) gene polymorphisms [27,28], so not everyone infected with EBV will develop cancer. In susceptible people, genome damage is permanent and does not require large numbers of viral particles, active infection, or continuing virus presence. Childhood immunization against selected EBV gene products may do much to prevent breast, ovarian, and other cancers.

Bernard Friedenson

JMIRx Med 2025;6:e50712

Deep Learning–Based Identification of Tissue of Origin for Carcinomas of Unknown Primary Using MicroRNA Expression: Algorithm Development and Validation

Deep Learning–Based Identification of Tissue of Origin for Carcinomas of Unknown Primary Using MicroRNA Expression: Algorithm Development and Validation

Micro RNAs belong to a class of noncoding regulatory RNAs, small single-stranded RNA molecules that are between 19 and 25 nucleotides long and are involved in the regulation of gene expression of m RNAs. Micro RNAs hold promise as informative biomarkers for cancer due to their significant involvement in cellular processes such as cell division, apoptosis, proliferation, and oncogenesis [8].

Ananya Raghu, Anisha Raghu, Jillian F Wise

JMIR Bioinform Biotech 2024;5:e56538

Peer Review of “Establishment of a Novel Fetal Ovine Heart Cell Line by Spontaneous Cell Fusion: Experimental Study”

Peer Review of “Establishment of a Novel Fetal Ovine Heart Cell Line by Spontaneous Cell Fusion: Experimental Study”

Detailing the cell line’s potential for broader biotechnological uses, such as in gene therapy or tissue engineering, would underscore its utility. 9. A discussion on the safety and regulatory aspects related to the cell line’s application in vaccine production, including tumorigenicity risks and quality control adherence, is essential. 10. Incorporating schematic illustrations to summarize the key findings and the spontaneous cell fusion development process would enhance the paper’s visual clarity. 11.

Hira Rafi

JMIRx Bio 2024;2:e63336

Authors’ Response to Peer Reviews of “Establishment of a Novel Fetal Ovine Heart Cell Line by Spontaneous Cell Fusion: Experimental Study”

Authors’ Response to Peer Reviews of “Establishment of a Novel Fetal Ovine Heart Cell Line by Spontaneous Cell Fusion: Experimental Study”

Detailing the cell line’s potential for broader biotechnological uses, such as in gene therapy or tissue engineering, would underscore its utility. Response: The cell line being permissive to many animal viruses, it might be a good future candidate for expression of vector viruses and plasmids and hence its possible utility in gene therapy. 9.

Khalid Suleiman, Mutaib Aljulidan, Gamaleldin Hussein, Habib Alkhalaf

JMIRx Bio 2024;2:e62911

Peer Review of “A Gene Therapy for Hereditary Nonpolyposis Colorectal Cancer using CRISPR-Cas9 Nickase”

Peer Review of “A Gene Therapy for Hereditary Nonpolyposis Colorectal Cancer using CRISPR-Cas9 Nickase”

This is a peer-review report submitted for the preprint “A Gene Therapy for Hereditary Nonpolyposis Colorectal Cancer using CRISPR-Cas9 Nickase.” This paper [1] investigates a gene therapy for hereditary nonpolyposis colorectal cancer using clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 nickase.

Chunbao Sun

JMIRx Bio 2023;1:e54743