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Title: “Herpesvirus infections eliminate safeguards against breast cancer and its metastasis: comparable to hereditary breast cancers”
The paper [
The hypothesis, while intriguing, needs clearer articulation. Specifically, the connection between EBV and breast cancer needs more explicit theoretical underpinning. Clarify the objectives and expected outcomes of the study at the outset.
While the bioinformatics approach is robust, it would benefit from a more detailed description of the methods and algorithms used. Additionally, the selection criteria for the breast cancer data should be justified more thoroughly to avoid selection bias.
The statistical methods used need more comprehensive detailing. For complex analyses, ensure the statistical assumptions and any transformations of data are clearly explained. Include more information on the statistical tests used for hypothesis testing and the justification for their use.
The comparison between hereditary breast cancers and those potentially caused by EBV is insightful. However, a more detailed comparative analysis would strengthen the argument. This could include molecular or genetic profiling comparisons.
The discussion section should address not only the supporting evidence but also any contradictory findings in the literature. This balance is crucial for a nuanced understanding of the subject.
The implications of these findings are profound but need clearer articulation. Discuss the potential impact on breast cancer treatment and prevention strategies. Also, outline future research directions, particularly in clinical or experimental studies, to confirm these bioinformatics findings.
Please add more background information about breast cancer (please cite: 1. Cao Y, Efetov S, He M, et al. Updated clinical perspectives and challenges of chimeric antigen receptor-T cell therapy in colorectal cancer and invasive breast cancer. Arch Immunol Ther Exp (Warsz). Aug 11, 2023;71(1):19. [doi: 10.1007/s00005-023-00684-x] [Medline: 37566162]; and 2. Liu Y, Lu S, Sun Y, et al. Deciphering the role of QPCTL in glioma progression and cancer immunotherapy. Front Immunol. Mar 29, 2023;14:1166377. [doi: 10.3389/fimmu.2023.1166377] [Medline: 37063864]).
The paper presents a novel and potentially significant hypothesis linking EBV to breast cancer. However, it requires major revisions to enhance its methodological rigor, clarity, and comprehensiveness. Addressing these concerns will significantly strengthen the manuscript’s impact and contribution to the field.
None declared.
Epstein-Barr virus