<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="reviewer-report"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id><journal-id journal-id-type="publisher-id">xmed</journal-id><journal-id journal-id-type="index">34</journal-id><journal-title>JMIRx Med</journal-title><abbrev-journal-title>JMIRx Med</abbrev-journal-title><issn pub-type="epub">2563-6316</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v7i1e101473</article-id><article-id pub-id-type="doi">10.2196/101473</article-id><article-categories><subj-group subj-group-type="heading"><subject>Peer-Review Report</subject></subj-group></article-categories><title-group><article-title>Peer Review of &#x201C;Chaotic and Stochastic Components in an Influenza Surveillance Series: Nonlinear Dynamics and Predictive Modeling Study&#x201D;</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>El Khamlichi</surname><given-names>Sokaina</given-names></name><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>Ibn Zohr University</institution><addr-line>Agadir</addr-line><country>Morocco</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Schwartz</surname><given-names>Amy</given-names></name></contrib></contrib-group><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>5</day><month>6</month><year>2026</year></pub-date><volume>7</volume><elocation-id>e101473</elocation-id><history><date date-type="received"><day>15</day><month>05</month><year>2026</year></date><date date-type="accepted"><day>15</day><month>05</month><year>2026</year></date></history><copyright-statement>&#x00A9; Sokaina El Khamlichi. Originally published in JMIRx Med (<ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org">https://med.jmirx.org</ext-link>), 5.6.2026. </copyright-statement><copyright-year>2026</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org/">https://med.jmirx.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://xmed.jmir.org/2026/1/e101473"/><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.1101/2025.07.09.25331183" xlink:title="Preprint (medRxiv Preprints)" xlink:type="simple">https://www.medrxiv.org/content/10.1101/2025.07.09.25331183v1</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/101688" xlink:title="Authors' Response to Peer-Review Reports" xlink:type="simple">https://med.jmirx.org/2026/1/e101688</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/81547" xlink:title="Published Article" xlink:type="simple">https://med.jmirx.org/2026/1/e81547</related-article><kwd-group><kwd>epidemiology</kwd><kwd>epidemiologic methods</kwd><kwd>epidemiological monitoring</kwd><kwd>chaos theory</kwd><kwd>topological data analysis</kwd><kwd>autoregressive conditional heteroskedasticity</kwd></kwd-group></article-meta></front><body><p><italic>This is a peer-review report for &#x201C;Chaotic and Stochastic Components in an Influenza Surveillance Series: Nonlinear Dynamics and Predictive Modeling Study.&#x201D;</italic></p><sec id="s2"><title>Round 1 Review</title><sec id="s1-1"><title>General Comments</title><p>This paper [<xref ref-type="bibr" rid="ref1">1</xref>] presents an interesting application of chaos theory, nonlinear time series analysis, and topological machine learning to influenza epidemiological data. The methodology is strong and promising. However, the manuscript requires substantial improvements to enhance clarity and accessibility.</p></sec><sec id="s1-2"><title>Specific Comments</title><sec id="s1-2-1"><title>Major Comments</title><p>1. Abstract: Currently very dense, heavy with jargon, and difficult for nonspecialists to follow. Please simplify sentences and clearly highlight the main objective, methodology, key findings, and implications.</p><p>2. Introduction: Starts too technically. Begin with a motivation, for instance, &#x201C;Why chaos theory in epidemiology?&#x201D; and then gradually introduce deterministic vs stochastic chaos. Also, state the study&#x2019;s aim more explicitly.</p><p>3. Methods: The section is lengthy, with equations embedded in the text. Consider dividing into subsections for readability. Moving some theoretical background to an appendix would also improve flow. Please add a figure summarizing the main steps of the study.</p><p>4. Results: The analysis is rich but scattered. Figures and tables are described without sufficient interpretation. For each, explicitly state the following: What do we see? What does it mean? Why does it matter?</p><p>5. Discussion: A separate Discussion section would strengthen the paper. You can structure it as follows: evidence of stochastic chaos in influenza, implications for epidemiological modeling and prediction, and comparison with previous applications of chaos theory.</p><p>6. Conclusion: Currently too technical and lacks a clear take-home message. Please make it concise, accessible, and impact-driven.</p></sec><sec id="s1-2-2"><title>Minor Comments</title><p>7. Language and style: Reduce the frequent repetition of the phrase &#x201C;stochastic chaotic.&#x201D; Simplify overly long sentences for better readability.</p></sec></sec></sec><sec id="s3"><title>Round 2 Review</title><sec id="s2-1"><title>General Comments</title><p>This paper presents an interesting and technically rich application of chaos theory, nonlinear time series analysis, and topological machine learning to influenza epidemiological data. The methodology is strong, and the topic is relevant for epidemiological modeling and risk analysis.</p><p>The authors have made some efforts to improve the manuscript following the first round of review, particularly in terms of organization and presentation. However, while progress has been made, several of the initial comments remain only partially addressed, and further revisions are required.</p></sec><sec id="s2-2"><title>Specific Comments</title><sec id="s2-2-1"><title>Major Comments</title><p>1. Although some improvements in clarity are noticeable, the manuscript remains dense and difficult to follow, particularly in the Abstract, Methods, and Results sections.</p><p>2. The Abstract remains too long and should be further simplified and condensed.</p><p>3. The structure of the Methods section could still be improved. The addition of a clear workflow diagram summarizing the methodology would greatly enhance readability.</p><p>4. The Results section continues to lack sufficient interpretation of figures and tables. The authors should more clearly explain what each result shows and why it is important.</p></sec></sec></sec><sec id="s4"><title>Round 3 Review</title><sec id="s3-1"><title>General Comments</title><p>The manuscript presents a technically solid and original study combining chaos theory, nonlinear time series analysis, and machine learning methods for influenza surveillance data. The authors have addressed the main concerns raised during the review process, particularly regarding the organization of the methodology and the interpretation of the results.</p><p>The paper provides a substantial amount of analysis, and the conclusions are generally supported by the reported findings. While some sections remain relatively dense and could still benefit from minor language polishing and simplification, the manuscript is now sufficiently clear and coherent for publication.</p></sec></sec></body><back><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>dos Santos Goncalves</surname><given-names>CP</given-names> </name><name name-style="western"><surname>Rouco</surname><given-names>C</given-names> </name></person-group><article-title>Chaotic and Stochastic Components in an Influenza Surveillance Series: Nonlinear Dynamics and Predictive Modeling Study</article-title><source>JMIRx Med</source><year>2026</year><volume>7</volume><fpage>e81547</fpage><pub-id pub-id-type="doi">10.2196/81547</pub-id></nlm-citation></ref></ref-list></back></article>