<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="reviewer-report"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id><journal-id journal-id-type="publisher-id">xmed</journal-id><journal-id journal-id-type="index">34</journal-id><journal-title>JMIRx Med</journal-title><abbrev-journal-title>JMIRx Med</abbrev-journal-title><issn pub-type="epub">2563-6316</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v6i1e84443</article-id><article-id pub-id-type="doi">10.2196/84443</article-id><article-categories><subj-group subj-group-type="heading"><subject>Peer-Review Report</subject></subj-group></article-categories><title-group><article-title>Peer Review of &#x201C;Development of a Conversational Artificial Intelligence&#x2013;Based Web Application for Medical Consultations: Prototype Study&#x201D;</article-title></title-group><contrib-group><contrib contrib-type="author"><collab>Anonymous</collab></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Leung</surname><given-names>Tiffany</given-names></name></contrib></contrib-group><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>15</day><month>10</month><year>2025</year></pub-date><volume>6</volume><elocation-id>e84443</elocation-id><history><date date-type="received"><day>19</day><month>09</month><year>2025</year></date><date date-type="accepted"><day>19</day><month>09</month><year>2025</year></date></history><copyright-statement>&#x00A9; Anonymous. Originally published in JMIRx Med (<ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org">https://med.jmirx.org</ext-link>), 15.10.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org/">https://med.jmirx.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://xmed.jmir.org/2025/1/e84443"/><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.1101/2023.12.31.23300681" xlink:title="Preprint (medRxiv)" xlink:type="simple">https://www.medrxiv.org/content/10.1101/2023.12.31.23300681v1</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/83417" xlink:title="Authors' Response to Peer-Review Reports" xlink:type="simple">https://med.jmirx.org/2025/1/e83417</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/56090" xlink:title="Published Article" xlink:type="simple">https://med.jmirx.org/2025/1/e56090</related-article><kwd-group><kwd>artificial intelligence</kwd><kwd>ChatGPT</kwd><kwd>chatbots</kwd><kwd>conversational agent</kwd><kwd>machine learning</kwd></kwd-group></article-meta></front><body><p><italic>This is the peer-review report for &#x201C;Development of a Conversational Artificial Intelligence&#x2013;Based Web Application for Medical Consultations: Prototype Study.&#x201D;</italic></p><sec id="s2"><title>Round 1 Review</title><sec id="s1-1"><title>General Comments</title><p>This paper [<xref ref-type="bibr" rid="ref1">1</xref>] presents a novel conversational artificial intelligence (AI) that is built on top of several models capable of detecting various health conditions. The research itself is interesting, relevant, and carried out well. I look forward to seeing the revised work!</p></sec><sec id="s1-2"><title>Specific Comments</title><sec id="s1-2-1"><title>Major Comments</title><list list-type="order"><list-item><p>Please strongly consider rechecking the grammar for the paper as I found several mistakes and inconsistencies in just the Abstract alone. Grammar issues have made it difficult to follow several lines of thought throughout the paper and have lowered its overall quality. Furthermore, the style of writing is more conversational than it is formal and academic in several cases. This is my main reason for rejecting the paper. Please address these issues and then resubmit.</p></list-item><list-item><p>Because the experience is integrated into a chatbot, indicating that providing an interactive user experience was a goal of this work, it would be good to also conduct some user research to assess the usability of the system and participants&#x2019; impressions of it.</p></list-item><list-item><p>It is important to also include a section discussing the potential dangers and ethical implications of deploying such a chatbot in the real world given the sensitive context and its critical implications.</p></list-item></list></sec><sec id="s1-2-2"><title>Minor Comments</title><list list-type="order" prefix-word="4"><list-item><p>I find the opening sentence of the Abstract and Introduction (&#x201C;Artificial intelligence (AI) evolved in trends. Currently, the trend is conversational artificial intelligence (CAI).&#x201D;) to be problematic. It is unclear what the statement &#x201C;AI evolved in trends&#x201D; means and therefore it is difficult to evaluate its accuracy. Furthermore, it would be more apt to say that the trend now is generative AI, which translates to large language models, that is fuelling conversational AI. It is also worth noting that conversational AI is not just focused on text-based interactions, but also includes voice modalities.</p></list-item></list></sec></sec></sec><sec id="s3"><title>Round 2 Review</title><sec id="s2-1"><title>General Comments</title><p>Thank you to the authors for reading our comments and revising the paper. Many of our previous comments have been addressed; however, I still believe the writing style, grammar, and language of the paper need significant work before this can be published.</p></sec></sec></body><back><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">AI</term><def><p>artificial intelligence</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Pires</surname><given-names>JG</given-names> </name></person-group><article-title>Development of a Conversational Artificial Intelligence&#x2013;Based Web Application for Medical Consultations: Prototype Study</article-title><source>JMIRx Med</source><year>2025</year><volume>URL</volume><fpage>e56090</fpage><pub-id pub-id-type="doi">10.2196/56090</pub-id></nlm-citation></ref></ref-list></back></article>