<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="reviewer-report"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id><journal-id journal-id-type="publisher-id">xmed</journal-id><journal-id journal-id-type="index">34</journal-id><journal-title>JMIRx Med</journal-title><abbrev-journal-title>JMIRx Med</abbrev-journal-title><issn pub-type="epub">2563-6316</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v6i1e82071</article-id><article-id pub-id-type="doi">10.2196/82071</article-id><article-categories><subj-group subj-group-type="heading"><subject>Peer-Review Report</subject></subj-group></article-categories><title-group><article-title>Peer Review of &#x201C;Challenges in Implementing a Mobile AI Chatbot Intervention for Depression Among Youth on Psychiatric Waiting Lists: Randomized Controlled Study Termination Report&#x201D;</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Ennis</surname><given-names>Edel</given-names></name><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>University of Ulster, School of Psychology</institution><addr-line>Coleraine</addr-line><country>United Kingdom</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Amal</surname><given-names>Saeed</given-names></name></contrib></contrib-group><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>5</day><month>9</month><year>2025</year></pub-date><volume>6</volume><elocation-id>e82071</elocation-id><history><date date-type="received"><day>08</day><month>08</month><year>2025</year></date><date date-type="accepted"><day>08</day><month>08</month><year>2025</year></date></history><copyright-statement>&#x00A9; Edel Ennis. Originally published in JMIRx Med (<ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org">https://med.jmirx.org</ext-link>), 5.9.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org/">https://med.jmirx.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://xmed.jmir.org/2025/1/e82071"/><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.1101/2024.11.25.24317880v1" xlink:title="Preprint (medRxiv)" xlink:type="simple">https://www.medrxiv.org/content/10.1101/2024.11.25.24317880v1</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/82083" xlink:title="Authors' Response to Peer-Review Reports" xlink:type="simple">https://med.jmirx.org/2025/1/e82083</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/70960" xlink:title="Published Article" xlink:type="simple">https://med.jmirx.org/2025/1/e70960</related-article><kwd-group><kwd>randomized controlled trial</kwd><kwd>AI chatbot</kwd><kwd>acceptance and commitment therapy</kwd><kwd>mental health</kwd><kwd>psychiatry</kwd><kwd>children</kwd><kwd>adolescents</kwd><kwd>Japan</kwd></kwd-group></article-meta></front><body><p><italic>This is a peer-review report for &#x201C;Challenges in Implementing a Mobile AI Chatbot Intervention for Depression Among Youth on Psychiatric Waiting Lists: Randomized Controlled Study Termination Report.&#x201D;</italic></p><sec id="s2"><title>Round 1 Review</title><p>Thank you for inviting me to review this paper [<xref ref-type="bibr" rid="ref1">1</xref>]. However, my suggestion would be that this paper should be rejected. I am very cognizant of publication biases, and I am a firm believer that the publication of negative results is very important. I therefore have no problem with the fact that the sample decreased to zero. However, I do believe that more detail is needed in terms of <italic>why</italic> people disengaged. The rationale for the paper is set up as efficacy of the intervention, but the main message of the paper is that the sample declined. I would therefore like more emphasis on qualitative interviews that examined why people disengaged. Follow-up work such as this would make a very interesting paper.</p></sec></body><back><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Fujita</surname><given-names>J</given-names> </name><name name-style="western"><surname>Yano</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Shinoda</surname><given-names>S</given-names> </name><etal/></person-group><article-title>Challenges in implementing a mobile AI chatbot intervention for depression among youth on psychiatric waiting lists: randomized controlled study termination report</article-title><source>JMIRx Med</source><year>2025</year><volume>6</volume><fpage>e70960</fpage><pub-id pub-id-type="doi">10.2196/70960</pub-id></nlm-citation></ref></ref-list></back></article>