<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="reviewer-report"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id><journal-id journal-id-type="publisher-id">xmed</journal-id><journal-id journal-id-type="index">34</journal-id><journal-title>JMIRx Med</journal-title><abbrev-journal-title>JMIRx Med</abbrev-journal-title><issn pub-type="epub">2563-6316</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v6i1e72525</article-id><article-id pub-id-type="doi">10.2196/72525</article-id><article-categories><subj-group subj-group-type="heading"><subject>Peer-Review Report</subject></subj-group></article-categories><title-group><article-title>Peer Review of &#x201C;Data Obfuscation Through Latent Space Projection for Privacy-Preserving AI Governance: Case Studies in Medical Diagnosis and Finance Fraud Detection&#x201D;</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Bommhardt</surname><given-names>Trutz</given-names></name><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>University of Wuppertal</institution><addr-line>Wuppertal</addr-line><country>Germany</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Hang</surname><given-names>Ching Nam</given-names></name></contrib></contrib-group><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>12</day><month>3</month><year>2025</year></pub-date><volume>6</volume><elocation-id>e72525</elocation-id><history><date date-type="received"><day>11</day><month>02</month><year>2025</year></date><date date-type="accepted"><day>11</day><month>02</month><year>2025</year></date></history><copyright-statement>&#x00A9; Trutz Bommhardt. Originally published in JMIRx Med (<ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org">https://med.jmirx.org</ext-link>), 12.3.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org/">https://med.jmirx.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://xmed.jmir.org/2025/1/e72525"/><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.48550/arXiv.2410.17459" xlink:title="Preprint (arXiv)" xlink:type="simple">https://arxiv.org/abs/2410.17459v1</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/72527" xlink:title="Authors' Response to Peer-Review Reports" xlink:type="simple">https://med.jmirx.org/2025/1/e72527</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/70100" xlink:title="Published Article" xlink:type="simple">https://med.jmirx.org/2025/1/e70100</related-article><kwd-group><kwd>privacy-preserving AI</kwd><kwd>latent space projection</kwd><kwd>data obfuscation</kwd><kwd>AI Governance</kwd><kwd>machine learning privacy</kwd><kwd>differential privacy</kwd><kwd>k-anonymity</kwd><kwd>HIPAA</kwd><kwd>GDPR</kwd><kwd>compliance</kwd><kwd>data utility</kwd><kwd>privacy-utility trade-off</kwd><kwd>responsible AI</kwd><kwd>medical imaging privacy</kwd><kwd>secure data sharing</kwd><kwd>LSP</kwd><kwd>artificial intelligence</kwd></kwd-group></article-meta></front><body><p><italic>This is a peer-review report for &#x201C;Data Obfuscation Through Latent Space Projection for Privacy-Preserving AI Governance: Case Studies in Medical Diagnosis and Finance Fraud Detection.&#x201D;</italic></p><sec id="s2"><title>Round 1 Review</title><sec id="s1-1"><title>General Comments</title><p>I thoroughly enjoyed reading this paper [<xref ref-type="bibr" rid="ref1">1</xref>] as it is a well-written article that will make an important contribution to the literature on the development of privacy-preserving artificial intelligence (AI) governance. I have attached a few comments to improve the study.</p></sec><sec id="s1-2"><title>Specific Comments</title><sec id="s1-2-1"><title>Major Comments</title><p>Something like a discussion that embeds the latent space projection for AI governance and the results in the current scientific debate is missing before or after Chapter VII.</p></sec><sec id="s1-2-2"><title>Minor Comments</title><p>In Chapter II B (Existing privacy-preserving techniques), please provide some further sources to demonstrate that the challenges mentioned are still relevant, as some sources are relatively old (eg, from 2009).</p></sec></sec></sec></body><back><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">AI</term><def><p>artificial intelligence</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Vaijainthymala Krishnamoorthy</surname><given-names>M</given-names> </name></person-group><article-title>Data Obfuscation Through Latent Space Projection for Privacy-Preserving AI Governance: Case Studies in Medical Diagnosis and Finance Fraud Detection</article-title><source>JMIRx Med</source><year>2025</year><volume>6</volume><fpage>e70100</fpage><pub-id pub-id-type="doi">10.2196/70100</pub-id></nlm-citation></ref></ref-list></back></article>