JMIRx Medxmed34JMIRx MedJMIRx Med2563-6316JMIR PublicationsToronto, Canadav6i1e6876910.2196/68769Authors’ Response To Peer ReviewsAuthors’ Response to Peer Reviews of “Applications of Indocyanine Green in Breast Cancer for Sentinel Lymph Node Mapping: Protocol for a Scoping Review”KurdiFeryalMD*KurdiYahyaMD*ReshetovIgor VladimirovichMD, PhDDepartment of Oncology, Radiotherapy and Plastic and Reconstructive Surgery, Sechenov UniversityBolshaya Pirogovskaya, 6c1MoscowRussian FederationTungjitviboonkunSongpholCorrespondence to Feryal Kurdi, MD, Department of Oncology, Radiotherapy and Plastic and Reconstructive Surgery, Sechenov University, Bolshaya Pirogovskaya, 6c1, Moscow, 119021, Russian Federation, 7 9013488810; dr.kurdiferyal@gmail.com

these authors contributed equally

20256120256e687691311202413112024© Feryal Kurdi, Yahya Kurdi, Igor Vladimirovich Reshetov. Originally published in JMIRx Med (https://med.jmirx.org), 6.1.2025. 2025

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on https://med.jmirx.org/, as well as this copyright and license information must be included.

https://www.medrxiv.org/content/10.1101/2024.07.30.24311256v1https://med.jmirx.org/2025/1/e69705https://med.jmirx.org/2025/1/e66213indocyanine greenICGsentinel lymph nodebreast cancerbreastfluorescenceaxillary lymph node mappingNIRsurgical planningnear-infrared

This is the authors’ response to peer-review reports for “Applications of Indocyanine Green in Breast Cancer for Sentinel Lymph Node Mapping: Protocol for a Scoping Review.”

Round 1 ReviewAnonymous [<xref ref-type="bibr" rid="ref1">1</xref>]General Comments

This paper [2] summarized the application value and existing problems of indocyanine green (ICG) in sentinel lymph node (SLN) biopsy of early breast cancer, which has positive significance for improving the accuracy of clinical SLN detection. This study has certain clinical value.

Response: Thank you for your thoughtful comments and feedback on our paper. Below are my responses to your points.

Specific CommentsMajor Comments

1. Due to the high hardware requirements for the clinical application of ICG, the number of relevant studies in the search is relatively small. It is hoped that the author can search the recent, relevant literature to improve the credibility of this review.

Response: This paper is a protocol for a scoping review, serving as a roadmap for the search strategy and inclusion criteria that we will follow. As such, it outlines our plan rather than reporting the outcomes of the literature search. As noted in Multimedia Appendix 1, we will conduct a comprehensive search across multiple databases to ensure the inclusion of all relevant, recent studies.

2. It is hoped that the author will analyze and compare the advantages and disadvantages of ICG and traditional SLN biopsy methods, so as to guide clinicians to adopt appropriate methods for appropriate patients.

Response: As indicated in Multimedia Appendix 1, this comparison is a core objective of our review. We hope these clarifications address your concerns.

AbbreviationsICG

indocyanine green

SLN

sentinel lymph node

ReferencesAnonymousPeer review of "Applications of Indocyanine Green in Breast Cancer for Sentinel Lymph Node Mapping: Protocol for a Scoping ReviewJMIRx Med20245e6970510.2196/69705KurdiF KurdiY ReshetovIV Applications of indocyanine green in breast cancer for sentinel lymph node mapping: protocol for a scoping reviewJMIRx Med20245e6621310.2196/66213