<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="reviewer-report"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id><journal-id journal-id-type="publisher-id">xmed</journal-id><journal-id journal-id-type="index">34</journal-id><journal-title>JMIRx Med</journal-title><abbrev-journal-title>JMIRx Med</abbrev-journal-title><issn pub-type="epub">2563-6316</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v5i1e67404</article-id><article-id pub-id-type="doi">10.2196/67404</article-id><article-categories><subj-group subj-group-type="heading"><subject>Peer-Review Report</subject></subj-group></article-categories><title-group><article-title>Peer Review of &#x201C;Beyond Expected Patterns in Insulin Needs of People With Type 1 Diabetes: Temporal Analysis of Automated Insulin Delivery Data&#x201D;</article-title></title-group><contrib-group><contrib contrib-type="author"><collab>Anonymous</collab></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Schwartz</surname><given-names>Amy</given-names></name></contrib></contrib-group><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>27</day><month>11</month><year>2024</year></pub-date><volume>5</volume><elocation-id>e67404</elocation-id><history><date date-type="received"><day>10</day><month>10</month><year>2024</year></date><date date-type="accepted"><day>10</day><month>10</month><year>2024</year></date></history><copyright-statement>&#x00A9; Anonymous. Originally published in JMIRx Med (<ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org">https://med.jmirx.org</ext-link>), 27.11.2024. </copyright-statement><copyright-year>2024</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org/">https://med.jmirx.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://xmed.jmir.org/2024/1/e67404"/><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.48550/arXiv.2211.07393" xlink:title="Preprint (arXiv)" xlink:type="simple">https://arxiv.org/abs/2211.07393v1</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/56993" xlink:title="Preprint (JMIR Preprints)" xlink:type="simple">http://preprints.jmir.org/preprint/44384</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/66643" xlink:title="Authors' Response to Peer-Review Reports" xlink:type="simple">https://med.jmirx.org/2024/1/e66643</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/44384" xlink:title="Published Article" xlink:type="simple">https://med.jmirx.org/2024/1/e44384</related-article><kwd-group><kwd>multivariate time series</kwd><kwd>k-means</kwd><kwd>clustering</kwd><kwd>machine learning</kwd><kwd>temporal patterns</kwd><kwd>data-driven</kwd><kwd>OpenAPS</kwd><kwd>open dataset</kwd><kwd>type 1 diabetes</kwd><kwd>insulin needs</kwd></kwd-group></article-meta></front><body><p><italic>This is a peer-review report for &#x201C;Beyond Expected Patterns in Insulin Needs of People With Type 1 Diabetes: Temporal Analysis of Automated Insulin Delivery Data.&#x201D;</italic></p><sec id="s2"><title>Round 1 Review</title><sec id="s1-1"><title>General Comments</title><p>Degen et al [<xref ref-type="bibr" rid="ref1">1</xref>] present the results of time series data derived from the OpenAPS data commons. The paper represents an important contribution to the field of diabetes technology research, as most of the work so far focused on clinical outcome analysis only. Pattern analysis of the device data provides useful insights for the entire open science community around open-source automated insulin delivery (AID) and will help researchers to identify their next research questions.</p><p>There are few papers on temporal patterns in AID research, which is why I support the publication of this comprehensive and well-written report.</p></sec><sec id="s1-2"><title>Specific Comments</title><list list-type="order"><list-item><p>Did the authors analyze any demographics from participants? This would be essential to exclude selection bias or at least highlight limitations if the sample is not representative of most users of open-source AID.</p></list-item><list-item><p>How many individual datasets were analyzed, and what is their total time span?</p></list-item><list-item><p>I suggest using &#x201C;interstitial glucose&#x201D; or &#x201C;sensor glucose&#x201D; versus blood glucose as continuous glucose monitoring sensors are usually placed subcutaneously and therefore do not measure (capillary) blood glucose.</p></list-item></list></sec></sec></body><back><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">AID</term><def><p>automated insulin delivery</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Degen</surname><given-names>I</given-names> </name><name name-style="western"><surname>Robson Brown</surname><given-names>K</given-names> </name><name name-style="western"><surname>Reeve</surname><given-names>HWJ</given-names> </name><name name-style="western"><surname>Abdallah</surname><given-names>ZS</given-names> </name></person-group><article-title>Beyond expected patterns in insulin needs of people with type 1 diabetes: temporal analysis of automated insulin delivery data</article-title><source>JMIRx Med</source><year>2024</year><volume>5</volume><fpage>e44384</fpage><pub-id pub-id-type="doi">10.2196/44384</pub-id></nlm-citation></ref></ref-list></back></article>