<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="reviewer-report"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id><journal-id journal-id-type="publisher-id">xmed</journal-id><journal-id journal-id-type="index">34</journal-id><journal-title>JMIRx Med</journal-title><abbrev-journal-title>JMIRx Med</abbrev-journal-title><issn pub-type="epub">2563-6316</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v5i1e66922</article-id><article-id pub-id-type="doi">10.2196/66922</article-id><article-categories><subj-group subj-group-type="heading"><subject>Peer-Review Report</subject></subj-group></article-categories><title-group><article-title>Peer Review of &#x201C;Beyond Expected Patterns in Insulin Needs of People With Type 1 Diabetes: Temporal Analysis of Automated Insulin Delivery Data&#x201D;</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Carvalho</surname><given-names>Darlinton</given-names></name><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>Computer Science Department, Universidade Federal de S&#x00E3;o Jo&#x00E3;o del Rei</institution>, <addr-line>S&#x00E3;o Jo&#x00E3;o del Rei</addr-line>, <country>Brazil</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Schwartz</surname><given-names>Amy</given-names></name></contrib></contrib-group><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>27</day><month>11</month><year>2024</year></pub-date><volume>5</volume><elocation-id>e66922</elocation-id><history><date date-type="received"><day>26</day><month>09</month><year>2024</year></date><date date-type="accepted"><day>26</day><month>09</month><year>2024</year></date></history><copyright-statement>&#x00A9; Darlinton Carvalho. Originally published in JMIRx Med (<ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org">https://med.jmirx.org</ext-link>), 27.11.2024. </copyright-statement><copyright-year>2024</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org/">https://med.jmirx.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://xmed.jmir.org/2024/1/e66922"/><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.48550/arXiv.2211.07393" xlink:title="Preprint (arXiv)" xlink:type="simple">https://arxiv.org/abs/2211.07393v1</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/56993" xlink:title="Preprint (JMIR Preprints)" xlink:type="simple">http://preprints.jmir.org/preprint/44384</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/66643" xlink:title="Authors' Response to Peer-Review Reports" xlink:type="simple">https://med.jmirx.org/2024/1/e66643</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/44384" xlink:title="Published Article" xlink:type="simple">https://med.jmirx.org/2024/1/e44384</related-article><kwd-group><kwd>multivariate time series</kwd><kwd>k-means</kwd><kwd>clustering</kwd><kwd>machine learning</kwd><kwd>temporal patterns</kwd><kwd>data-driven</kwd><kwd>OpenAPS</kwd><kwd>open dataset</kwd><kwd>type 1 diabetes</kwd><kwd>insulin needs</kwd></kwd-group></article-meta></front><body><p><italic>This is a peer-review report for &#x201C;Beyond Expected Patterns in Insulin Needs of People With Type 1 Diabetes: Temporal Analysis of Automated Insulin Delivery Data.&#x201D;</italic></p><sec id="s2"><title>Round 1 Review</title><sec id="s1-1"><title>General Comments</title><p>This paper presents a study [<xref ref-type="bibr" rid="ref1">1</xref>] about temporal patterns in insulin needs for type 1 diabetes. It employs various time series techniques to spot such patterns using matrix profiles and multivariate clustering. The OpenAPS Data Commons dataset, an extensive dataset collected in real-life conditions, was analyzed to discover temporal patterns in insulin needs driven by well-known factors such as carbohydrates and potentially novel factors. The results are limited to disclosing interesting temporal patterns in insulin need that cannot be explained solely by carbohydrates through the performed analysis. While patterns found are auspicious, they still lack scientific rigor and research into correlations and causalities that drive these patterns to truly inspire new research into type 1 diabetes.</p></sec><sec id="s1-2"><title>Specific Comments</title><sec id="s1-2-1"><title>Major Comments</title><list list-type="order"><list-item><p>The research is well-designed and developed.</p></list-item><list-item><p>Although the paper is well written and presents interesting results, it does not comply with the Instructions for Authors of JMIR [<xref ref-type="bibr" rid="ref2">2</xref>].</p></list-item><list-item><p>The discussion and implications are minimal, leaving a more significant contribution to future work.</p></list-item><list-item><p>This article [<xref ref-type="bibr" rid="ref3">3</xref>] is found in multiple publications on the internet.</p></list-item></list></sec></sec></sec></body><back><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Degen</surname><given-names>I</given-names> </name><name name-style="western"><surname>Robson Brown</surname><given-names>K</given-names> </name><name name-style="western"><surname>Reeve</surname><given-names>HWJ</given-names> </name><name name-style="western"><surname>Abdallah</surname><given-names>ZS</given-names> </name></person-group><article-title>Beyond expected patterns in insulin needs of people with type 1 diabetes: temporal analysis of automated insulin delivery data</article-title><source>JMIRx Med</source><year>2024</year><volume>5</volume><fpage>e44384</fpage><pub-id pub-id-type="doi">10.2196/44384</pub-id></nlm-citation></ref><ref id="ref2"><label>2</label><nlm-citation citation-type="web"><article-title>Instructions for authors of JMIR</article-title><source>JMIR</source><access-date>2024-11-04</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://www.jmir.org/content/author-instructions">https://www.jmir.org/content/author-instructions</ext-link></comment></nlm-citation></ref><ref id="ref3"><label>3</label><nlm-citation citation-type="preprint"><person-group person-group-type="author"><name name-style="western"><surname>Abdallah</surname><given-names>ZS</given-names> </name></person-group><article-title>Temporal patterns in insulin needs for type 1 diabetes</article-title><source>arXiv</source><comment>Preprint posted online on  Nov 17, 2022</comment><pub-id pub-id-type="doi">10.48550/arXiv.2211.07393</pub-id></nlm-citation></ref></ref-list></back></article>