JMIRx Medxmed34JMIRx MedJMIRx Med2563-6316JMIR PublicationsToronto, Canadav5i1e6435510.2196/64355Peer-Review ReportPeer Review of “Development and Assessment of a Point-of-Care Application (Genomic Medicine Guidance) for Heritable Thoracic Aortic Disease”AnonymousMeinertEdward202481020245e643551507202415072024© Anonymous. Originally published in JMIRx Med (https://med.jmirx.org), 8.10.2024. 2024

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https://www.medrxiv.org/content/10.1101/2023.12.22.23299696v1https://med.jmirx.org/2024/1/e64436https://med.jmirx.org/2024/1/e55903genomic medicinepoint of carethoracic aortic aneurysmaortic dissectiondecision support

This is a peer-review report for “Development and Assessment of a Point-of-Care Application (Genomic Medicine Guidance) for Heritable Thoracic Aortic Disease”

Round 1 ReviewGeneral Comments

This paper [1] highlights an important application of a point-of-care application in guiding clinicians in their management of patients. It will be of interest to the community served by the journal.

Specific CommentsMajor Comments

There needs to be some statistics on the “accuracy” of the application. For example, a number of expert clinicians in genomic medicine and its use (eg, 10) need to make clinical decisions without the use of the application, and then get 10 other clinicians who are not experts in genomic medicine to use the application and compare the level of agreement. A concordance study of this type needs to be done.

Round 2 ReviewGeneral Comments

With respect to my initial recommendation: There needs to be some statistics on the “accuracy” of the application. For example, a number of expert clinicians in genomic medicine and its use (eg, 10) need to make clinical decisions without the use of the application, and then get 10 other clinicians who are not experts in genomic medicine to use the application and compare the level of agreement. A concordance study of this type needs to be done.

Specific CommentsMajor Comments

This should not be beyond the scope of the manuscript. Without this information, the manuscript is not high impact but low impact or a niche interest. I recommend you pursuing this recommendation.

None declared.

ReferencesPatilR AshrafF Abu DayehS PrakashSK Development and Assessment of a Point-of-Care Application (Genomic Medicine Guidance) for Heritable Thoracic Aortic DiseaseJMIRx Med20245e5590310.2196/55903