<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="reviewer-report"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id><journal-id journal-id-type="publisher-id">xmed</journal-id><journal-id journal-id-type="index">34</journal-id><journal-title>JMIRx Med</journal-title><abbrev-journal-title>JMIRx Med</abbrev-journal-title><issn pub-type="epub">2563-6316</issn></journal-meta><article-meta><article-id pub-id-type="publisher-id">58321</article-id><article-id pub-id-type="doi">10.2196/58321</article-id><title-group><article-title>Peer Review of &#x201C;Detecting Substance Use Disorder Using Social Media Data and the Dark Web: Time- and Knowledge-Aware Study&#x201D;</article-title></title-group><contrib-group><contrib contrib-type="author"><collab>Anonymous</collab></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Meinert</surname><given-names>Edward</given-names></name></contrib></contrib-group><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>1</day><month>5</month><year>2024</year></pub-date><volume>5</volume><elocation-id>e58321</elocation-id><history><date date-type="received"><day>12</day><month>03</month><year>2024</year></date><date date-type="accepted"><day>12</day><month>03</month><year>2024</year></date></history><copyright-statement>&#x00A9; Anonymous. Originally published in JMIRx Med (<ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org">https://med.jmirx.org</ext-link>), 1.5.2024. </copyright-statement><copyright-year>2024</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org/">https://med.jmirx.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://xmed.jmir.org/2024/1/e58321"/><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/preprints.10512" xlink:title="Preprint (arXiv)" xlink:type="simple">https://arxiv.org/abs/2304.10512</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/57838" xlink:title="Authors&#x2019; Response to Peer-Review Reports" xlink:type="simple">https://med.jmirx.org/2024/1/e57838</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/48519" xlink:title="Published Article" xlink:type="simple">https://med.jmirx.org/2024/1/e48519</related-article><kwd-group><kwd>opioid</kwd><kwd>substance use</kwd><kwd>substance use disorder</kwd><kwd>social media</kwd><kwd>US</kwd><kwd>opioid crisis</kwd><kwd>mental health</kwd><kwd>substance misuse</kwd><kwd>crypto</kwd><kwd>dark web</kwd><kwd>users</kwd><kwd>user perception</kwd><kwd>fentanyl</kwd><kwd>synthetic opioids</kwd><kwd>United States</kwd></kwd-group></article-meta></front><body><p><italic>This is the peer-review report for &#x201C;Detecting Substance Use Disorder Using Social Media Data and the Dark Web: Time- and Knowledge-Aware Study.&#x201D;</italic></p><sec id="s2"><title>Round 1 Review</title><sec id="s1-1"><title>Comments for Authors</title><list list-type="order"><list-item><p>The paper [<xref ref-type="bibr" rid="ref1">1</xref>] is well written and easy to understand. See comments below for a summary description of the paper from my perspective.</p></list-item><list-item><p>However, I would have liked to see insights ideally established in the medical literature and supported by the experimental context in this paper (eg, those that can substantiate the prediction results and how this type of artificial intelligence can benefit substance use disorder [SUD]&#x2013;related outcomes).</p></list-item><list-item><p>Although a temporal pattern&#x2013;aware method is implemented in this paper, which is a big positive, I would like to see an analysis over two distinctly separate time periods to establish the consistency and robustness of the proposed approach.</p></list-item><list-item><p>Without addressing points 2 and 3, the utility of this work is fairly limited. I would suggest a detailed discussion of points 2 and 3 in a revised version of the paper before submission.</p></list-item></list></sec><sec id="s1-2"><title>Paper Summary</title><p>This paper presents a novel approach to SUD from social media posts crawled from various dark web sources. The pipeline is sufficiently novel and high-performing compared to the presented baselines and generally in isolation (80% plus is a good score). The authors specify the intended outcome of the study as establishing a relationship between the mention of drugs in posts versus SUD by analysis of the form of expression. The methodology, successes, and failures in detection are clearly stated and discussed.</p></sec></sec></body><back><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">SUD</term><def><p>substance use disorder</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Lokala</surname><given-names>U</given-names></name><name name-style="western"><surname>Phukan</surname><given-names>OC</given-names></name><name name-style="western"><surname>Dastidar</surname><given-names>TG</given-names></name><name name-style="western"><surname>Lamy</surname><given-names>F</given-names></name><name name-style="western"><surname>Daniulaityte</surname><given-names>R</given-names></name><name name-style="western"><surname>Sheth</surname><given-names>A</given-names></name></person-group><article-title>Detecting substance use disorder using social media data and the dark web: time- and knowledge-aware study</article-title><source>JMIRx Med</source><year>2024</year><volume>5</volume><fpage>e48519</fpage><pub-id pub-id-type="doi">10.2196/48519</pub-id></nlm-citation></ref></ref-list></back></article>