<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="reviewer-report"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id><journal-id journal-id-type="publisher-id">xmed</journal-id><journal-id journal-id-type="index">34</journal-id><journal-title>JMIRx Med</journal-title><abbrev-journal-title>JMIRx Med</abbrev-journal-title><issn pub-type="epub">2563-6316</issn></journal-meta><article-meta><article-id pub-id-type="publisher-id">58317</article-id><article-id pub-id-type="doi">10.2196/58317</article-id><title-group><article-title>Peer Review of &#x201C;Detecting Substance Use Disorder Using Social Media Data and the Dark Web: Time- and Knowledge-Aware Study&#x201D;</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Subramaniyan</surname><given-names>Vetriselvan</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>Pharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia</institution>, <addr-line>Sunway City</addr-line>, <country>Malaysia</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Meinert</surname><given-names>Edward</given-names></name></contrib></contrib-group><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>1</day><month>5</month><year>2024</year></pub-date><volume>5</volume><elocation-id>e58317</elocation-id><history><date date-type="received"><day>12</day><month>03</month><year>2024</year></date><date date-type="accepted"><day>12</day><month>03</month><year>2024</year></date></history><copyright-statement>&#x00A9; Vetriselvan Subramaniyan. Originally published in JMIRx Med (<ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org">https://med.jmirx.org</ext-link>), 1.5.2024. </copyright-statement><copyright-year>2024</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://med.jmirx.org/">https://med.jmirx.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://xmed.jmir.org/2024/1/e58317"/><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/preprints.10512" xlink:title="Preprint (arXiv)" xlink:type="simple">https://arxiv.org/abs/2304.10512</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/57838" xlink:title="Authors&#x2019; Response to Peer-Review Reports" xlink:type="simple">https://med.jmirx.org/2024/1/e57838</related-article><related-article related-article-type="companion" ext-link-type="doi" xlink:href="10.2196/48519" xlink:title="Published Article" xlink:type="simple">https://med.jmirx.org/2024/1/e48519</related-article><kwd-group><kwd>opioid</kwd><kwd>substance use</kwd><kwd>substance use disorder</kwd><kwd>social media</kwd><kwd>US</kwd><kwd>opioid crisis</kwd><kwd>mental health</kwd><kwd>substance misuse</kwd><kwd>crypto</kwd><kwd>dark web</kwd><kwd>users</kwd><kwd>user perception</kwd><kwd>fentanyl</kwd><kwd>synthetic opioids</kwd><kwd>United States</kwd></kwd-group></article-meta></front><body><p><italic>This is the peer-review report for &#x201C;Detecting Substance Use Disorder Using Social Media Data and the Dark Web: Time- and Knowledge-Aware Study.&#x201D;</italic></p><sec id="s2"><title>Round 1 Review</title><p>The paper [<xref ref-type="bibr" rid="ref1">1</xref>] is titled &#x201C;&#x201C;Can We Detect Substance Use Disorder?&#x201D;: Knowledge and Time Aware Classification on Social Media from Darkweb.&#x201D;</p><sec id="s1-1"><title>General Comments</title><list list-type="order"><list-item><p>The paper has been written comprehensively.</p></list-item><list-item><p>The study aims to analyze substance use posts on social media from the dark web and detect substance use disorder using appropriately developed state-of-the-art deep learning and knowledge-aware Bidirectional Encoder Representations From Transformers&#x2013;based models.</p></list-item><list-item><p>Topic analysis is performed to appropriately identify correlations between different drugs and the topics discussed in social media posts.</p></list-item><list-item><p>The most effective model achieves statistically significant performance (macro&#x2013;F<sub>1</sub>-score 82.12, recall 83.58) in accurately identifying substance use disorder.</p></list-item></list></sec><sec id="s1-2"><title>Minor Comments</title><p>1. The study acknowledges the challenges of crawling crypto markets and the restricted crawling process, which limits the data available for analysis.</p><p>Need to explain in the manuscript.</p><p>2. The study proposes building an opioid drug social media knowledge graph but does not provide details on the potential impact or implications of such a graph.</p><p>Need to provide the details in the manuscript.</p><p>3. The study explicitly states that it does not make any clinical diagnosis or treatment suggestions, which indicates a gap in translating the research findings into practical applications for addressing substance use disorder.</p><p>Need to justify how this study will be helpful for clinical situations.</p></sec><sec id="s1-3"><title>Report</title><p>After incorporating the suggested comments, this paper is suitable for publication in the <italic>Journal of Medical Internet Research</italic>.</p></sec></sec></body><back><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Lokala</surname><given-names>U</given-names></name><name name-style="western"><surname>Phukan</surname><given-names>OC</given-names></name><name name-style="western"><surname>Dastidar</surname><given-names>TG</given-names></name><name name-style="western"><surname>Lamy</surname><given-names>F</given-names></name><name name-style="western"><surname>Daniulaityte</surname><given-names>R</given-names></name><name name-style="western"><surname>Sheth</surname><given-names>A</given-names></name></person-group><article-title>Detecting substance use disorder using social media data and the dark web: time- and knowledge-aware study</article-title><source>JMIRx Med</source><year>2024</year><volume>5</volume><fpage>e48519</fpage><pub-id pub-id-type="doi">10.2196/48519</pub-id></nlm-citation></ref></ref-list></back></article>