<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "http://dtd.nlm.nih.gov/publishing/2.0/journalpublishing.dtd">
<?covid-19-tdm?>
<article article-type="article-commentary" dtd-version="2.0" xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIRxMed</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id>
      <journal-title>JMIRx Med</journal-title>
      <issn pub-type="epub">2563-6316</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v4i1e46906</article-id>
      <article-id pub-id-type="pmid"/>
      <article-id pub-id-type="doi">10.2196/46906</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Peer-Review Report</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Peer-Review Report</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Peer Review of “The Impact of SARS-CoV-2 Lineages (Variants) and COVID-19 Vaccination on the COVID-19 Epidemic in South Africa: Regression Study”</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Meinert</surname>
            <given-names>Edward</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="no">
          <name name-style="western">
            <surname>Poluru</surname>
            <given-names>Ramesh</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7693-418X</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>The INCLEN Trust International</institution>
        <addr-line>New Delhi</addr-line>
        <country>India</country>
      </aff>
      <pub-date pub-type="collection">
        <year>2023</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>3</day>
        <month>7</month>
        <year>2023</year>
      </pub-date>
      <volume>4</volume>
      <elocation-id>e46906</elocation-id>
      <history>
        <date date-type="received">
          <day>1</day>
          <month>3</month>
          <year>2023</year>
        </date>
        <date date-type="accepted">
          <day>1</day>
          <month>3</month>
          <year>2023</year>
        </date>
      </history>
      <copyright-statement>©Ramesh Poluru. Originally published in JMIRx Med (https://med.jmirx.org), 03.07.2023.</copyright-statement>
      <copyright-year>2023</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on https://med.jmirx.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://med.jmirx.org/2023/1/e46906" xlink:type="simple"/>
      <related-article related-article-type="companion" id="preprint34598" ext-link-type="doi" xlink:href="https://doi.org/10.2196/preprints.34598" vol="1" page="e34598" xlink:title="Preprint:" xlink:type="simple">https://preprints.jmir.org/preprint/34598</related-article>
      <related-article related-article-type="companion" id="v4i1e46944" ext-link-type="doi" xlink:href="10.2196/46944" vol="4" page="e46944" xlink:title="Authors' Response to Peer-Review Reports:" xlink:type="simple">https://med.jmirx.org/2023/1/e46944/</related-article>
      <related-article related-article-type="companion" id="v4i1e34598" ext-link-type="doi" xlink:href="10.2196/34598" vol="4" page="e34598" xlink:title="Published Article:" xlink:type="simple">https://med.jmirx.org/2023/1/e34598/</related-article>
      <kwd-group>
        <kwd>COVID-19</kwd>
        <kwd>infection</kwd>
        <kwd>pandemic</kwd>
        <kwd>vaccine</kwd>
        <kwd>vaccination</kwd>
        <kwd>epidemiology</kwd>
        <kwd>transmissibility</kwd>
        <kwd>health care</kwd>
        <kwd>hospital admission</kwd>
        <kwd>COVID-19 variants</kwd>
        <kwd>SARS-CoV-2</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <p>
      <italic>This is a peer-review report submitted for the paper “The Impact of SARS-CoV-2 Lineages (Variants) and COVID-19 Vaccination on the COVID-19 Epidemic in South Africa: Regression Study.”</italic>
    </p>
    <sec>
      <title>Round 1 Review</title>
      <p>The manuscript [<xref ref-type="bibr" rid="ref1">1</xref>] attempts to investigate the impact of SARS-CoV-2 lineages in South African COVID-19 epidemiology. I would like to congratulate the authors on this useful attempt. The manuscript is well written, and the subject addressed in this manuscript is worth investigating; however, the manuscript partly failed to present a clear picture of its analytical methodology and presentation of results. The following are some minor concerns for consideration. I suggest that the authors (a) extend the study to include the recent Omicron variant, (b) present results with complete models, (c) avoid excessive references (~71).</p>
      <p>In conclusion, the subject addressed in this manuscript is worth investigating and acceptable after taking into account the abovementioned minor issues.</p>
    </sec>
  </body>
  <back>
    <app-group/>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Mabuka</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Naidoo</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Ncube</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Yiga</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Ross</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Kurehwa</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Nare</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Silaji</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Ndemera</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Lemeke</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Taiwo</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Macharia</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Sithole</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>The impact of SARS-CoV-2 lineages (variants) and COVID-19 vaccination on the COVID-19 epidemic in South Africa: regression study</article-title>
          <source>JMIRx Med</source>
          <year>2023</year>
          <volume>4</volume>
          <fpage>e34598</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://med.jmirx.org/2023/1/e34598/"/>
          </comment>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
