JMIRxMed JMIRx Med JMIRx Med 2563-6316 JMIR Publications Toronto, Canada v4i1e45308 10.2196/45308 Peer-Review Report Peer-Review Report Peer Review for " Postacute Sequelae of COVID-19 and Adverse Psychiatric Outcomes: Protocol for an Etiology and Risk Systematic Review" Eysenbach Gunther Griffin Daniel MD, PhD 1 https://orcid.org/0000-0001-5853-6906 Columbia University New York City, NY United States 2023 14 3 2023 4 e45308 23 12 2022 23 12 2022 ©Daniel Griffin. Originally published in JMIRx Med (https://med.jmirx.org), 14.03.2023. 2023

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 https://preprints.jmir.org/preprint/43880 https://med.jmirx.org/2023/1/e43880/ COVID-19 long COVID post–COVID-19 condition postacute sequelae of COVID-19 PASC psychiatry epidemiology evidence-based medicine

This is a peer-review report submitted for the paper “Postacute Sequelae of COVID-19 and Adverse Psychiatric Outcomes: Protocol for an Etiology and Risk Systematic Review.”

Round 2 Review General Comments

The authors lay out a reasonable protocol for this type of investigation [1].

 Serious Concerns

Do you have any serious concerns about the manuscript such as fraud, plagiarism, unethical or unsafe practices?

No.

Have authors’ provided the necessary ethics approval (from authors’ institution or an ethics committee)?

Yes.

 Language Quality

How would you rate the English language quality?

High quality.

 Validity and Reproducibility

Is the reasons for conducting the study and its objectives clearly explained?

Yes.

Is the study design appropriate?

Yes.

Are sufficient details provided so that the method can be replicated?

Yes.

Are datasets available so that others could use them?

Not applicable.

 Suggestions

Based on your answers in section 3 how could the author improve the protocol?

It is appropriate as it is.

Do you have any other feedback or comments for the Author?

The authors lay out a reasonable protocol for this type of investigation that is based on a fairly standard approach with the standard GRADE grading approach.

 Decision

Verified manuscript: The content is scientifically sound, and only minor amendments (if any) are suggested.

None declared.

Editorial Notice

This paper was peer-reviewed by the Plan P Hashtag Community partner #PeerRef.

 Effiong A Postacute sequelae of COVID-19 and adverse psychiatric outcomes: protocol for an etiology and risk systematic review JMIRx Med 2023 4 1 e43880