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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIRxMed</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id>
      <journal-title>JMIRx Med</journal-title>
      <issn pub-type="epub">2563-6316</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v3i2e38522</article-id>
      <article-id pub-id-type="pmid"/>
      <article-id pub-id-type="doi">10.2196/38522</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Peer-Review Report</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Peer-Review Report</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Peer Review of “The Influence of SARS-CoV-2 Variants on National Case-Fatality Rates: Correlation and Validation Study”</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Meinert</surname>
            <given-names>Edward</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="no">
          <name name-style="western">
            <surname>Poluru</surname>
            <given-names>Ramesh</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7693-418X</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>The INCLEN Trust International</institution>
        <addr-line>New Delhi</addr-line>
        <country>India</country>
      </aff>
      <pub-date pub-type="collection">
        <season>Apr-Jun</season>
        <year>2022</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>24</day>
        <month>5</month>
        <year>2022</year>
      </pub-date>
      <volume>3</volume>
      <issue>2</issue>
      <elocation-id>e38522</elocation-id>
      <history>
        <date date-type="received">
          <day>5</day>
          <month>4</month>
          <year>2022</year>
        </date>
        <date date-type="accepted">
          <day>5</day>
          <month>4</month>
          <year>2022</year>
        </date>
      </history>
      <copyright-statement>©Ramesh Poluru. Originally published in JMIRx Med (https://med.jmirx.org), 24.05.2022.</copyright-statement>
      <copyright-year>2022</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on https://med.jmirx.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://med.jmirx.org/2022/2/e38522" xlink:type="simple"/>
      <related-article related-article-type="companion" id="preprint2108.06820" ext-link-type="doi" xlink:href="10.48550" vol="1" page="2108.06820" xlink:title="Preprint (arxiv):" xlink:type="simple">https://arxiv.org/abs/2108.06820</related-article>
      <related-article related-article-type="companion" id="preprint32935" ext-link-type="doi" xlink:href="https://doi.org/10.2196/preprints.32935" vol="1" page="e32935" xlink:title="Preprint (JMIR Preprints):" xlink:type="simple">https://preprints.jmir.org/preprint/32935</related-article>
      <related-article related-article-type="companion" id="v3i2e38549" ext-link-type="doi" xlink:href="10.2196/38549" vol="2" page="e38549" xlink:title="Author's Response to Peer-Review Reports:" xlink:type="simple">https://med.jmirx.org/2022/2/e38549/</related-article>
      <related-article related-article-type="companion" id="v3i2e32935" ext-link-type="doi" xlink:href="10.2196/32935" vol="2" page="e32935" xlink:title="Published Article:" xlink:type="simple">https://med.jmirx.org/2022/2/e32935/</related-article>
      <kwd-group>
        <kwd>SARS-CoV-2</kwd>
        <kwd>COVID-19</kwd>
        <kwd>variants of concern</kwd>
        <kwd>case-fatality rates</kwd>
        <kwd>virulence</kwd>
        <kwd>vaccine effectiveness</kwd>
        <kwd>correlation study</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <p>
      <italic>This is a peer-review report submitted for the paper “The Influence of SARS-CoV-2 Variants on National Case-Fatality Rates: Correlation and Validation Study.”</italic>
    </p>
    <sec>
      <title>Round 1 Review</title>
      <p>I would like to appreciate the author for this study [<xref ref-type="bibr" rid="ref1">1</xref>] addressing the influence of SARS-CoV-2 variants on national case-fatality rates. The manuscript is concise and well written, and is recommended for possible consideration in its current form. Before publishing the manuscript, I suggest the author presents an Appendix with (a) data with absolute numbers, (b) illustration for smoothed values of the proxy case-fatality rate for at least one country (<xref rid="figure8" ref-type="fig">Figures 8</xref>-<xref rid="figure11" ref-type="fig">11</xref>), and (c) alternatively discussion on the analytical framework in detail in the Method of Analysis section.</p>
      <p>In conclusion, the subject addressed in this manuscript is worth investigation, and the manuscript is recommended for possible consideration after addressing the above minor concerns.</p>
    </sec>
  </body>
  <back>
    <app-group/>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Barletta</surname>
              <given-names>WA</given-names>
            </name>
          </person-group>
          <article-title>The influence of SARS-CoV-2 variants on national case-fatality rates: correlation and validation study</article-title>
          <source>JMIRx Med</source>
          <year>2022</year>
          <volume>3</volume>
          <issue>2</issue>
          <fpage>e32935</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://med.jmirx.org/2022/3/e32935/"/>
          </comment>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
