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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMed</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id>
      <journal-title>JMIRx Med</journal-title>
      <issn pub-type="epub">2563-6316</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v2i1e27536</article-id>
      <article-id pub-id-type="pmid"/>
      <article-id pub-id-type="doi">10.2196/27536</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Peer-Review Report</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Peer-Review Report</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Peer Review of “A Framework for a Statistical Characterization of Epidemic Cycles: COVID-19 Case Study”</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Meinert</surname>
            <given-names>Edward</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="no">
          <name name-style="western">
            <surname>Facente</surname>
            <given-names>Shelley N</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7266-352X</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
          <label>1</label>
          <country>United States</country>
          </aff>
      <pub-date pub-type="collection">
        <season>Jan-Mar</season>
        <year>2021</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>18</day>
        <month>3</month>
        <year>2021</year>
      </pub-date>
      <volume>2</volume>
      <issue>1</issue>
      <elocation-id>e27536</elocation-id>
      <history>
        <date date-type="received">
          <day>27</day>
          <month>1</month>
          <year>2021</year>
        </date>
        <date date-type="accepted">
          <day>27</day>
          <month>1</month>
          <year>2021</year>
        </date>
      </history>
      <copyright-statement>©Shelley N Facente. Originally published in JMIRx Med (https://med.jmirx.org), 18.03.2021.</copyright-statement>
      <copyright-year>2021</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on http://med.jmirx.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://xmed.jmir.org/2021/1/e27536" xlink:type="simple"/>
      <related-article related-article-type="companion" id="preprint22617" ext-link-type="doi" xlink:href="https://doi.org/10.2196/preprints.22617" vol="1" page="e22617" xlink:title="Preprint:" xlink:type="simple">https://preprints.jmir.org/preprint/22617</related-article>
      <related-article related-article-type="companion" id="v2i1e27537" ext-link-type="doi" xlink:href="10.2196/27537" vol="1" page="e27537" xlink:title="Author Responses to Peer-Review Reports:" xlink:type="simple">https://med.jmirx.org/2020/1/e27537/</related-article>
      <related-article related-article-type="companion" id="v2i1e22617" ext-link-type="doi" xlink:href="https://doi.org/10.2196/22617" vol="2" page="e22617" xlink:title="Published Article:" xlink:type="simple">https://med.jmirx.org/2021/1/e22617</related-article>
      <kwd-group>
        <kwd>COVID-19</kwd>
        <kwd>pandemics</kwd>
        <kwd>infection control</kwd>
        <kwd>models</kwd>
        <kwd>experimental</kwd>
        <kwd>longitudinal studies</kwd>
        <kwd>statistical modeling</kwd>
        <kwd>epidemiology</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <p>
      <italic>This is a peer review submitted for the paper “A Framework for a Statistical Characterization of Epidemic Cycles: COVID-19 Case Study.”</italic>
    </p>
    <sec>
      <title>Round 1 Review</title>
      <sec>
        <title>General Comments</title>
        <p>This paper [<xref ref-type="bibr" rid="ref1">1</xref>] attempts to make some interesting comparisons in epidemic curves but is far too long, requires a thorough copy edit by a native English speaker, and does not appear to be very scientific in nature—it would require a substantial overhaul in both methods and write-up to be suitable for publication in this journal.</p>
      </sec>
      <sec>
        <title>Specific Comments</title>
        <sec>
          <title>Major Comments</title>
          <list list-type="order">
            <list-item>
              <p>I think the paper would benefit from focusing on the central point, with only a minor description of any methods necessary to make that point. For example, most of section 2 (“On the Nature of the Observed Data”) includes a lengthy description of the use of moving averages and R<sup>2</sup> values, which readers can be expected to understand (and those who do not could learn via appropriate citations). Certainly, the formula for R<sup>2</sup> is not necessary to include. These types of revisions would make the paper a more readable length.</p>
            </list-item>
            <list-item>
              <p>The authors claim the Chinese epidemic cycle has a Gaussian shape, but even in their own drawing it appears much more like a gamma distribution (as would be expected) than Gaussian. They may want to reconsider this section.</p>
            </list-item>
            <list-item>
              <p>The crux of this paper seems to be looking for epidemic curves that appear similarly shaped in various countries, and using that to predict the curves for countries where the cycle has not yet reached what the authors term the “MLCE end.” I have never heard of epidemic predictions using a method such as this, and it seems there are many far superior methods for estimating trajectory, so this is a curious choice.</p>
            </list-item>
            <list-item>
              <p>Citations require appropriate formatting for journal publications.</p>
            </list-item>
          </list>
        </sec>
      </sec>
    </sec>
  </body>
  <back>
    <app-group/>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>De Carvalho</surname>
              <given-names>EA</given-names>
            </name>
            <name name-style="western">
              <surname>De Carvalho</surname>
              <given-names>RA</given-names>
            </name>
          </person-group>
          <article-title>A Framework for a Statistical Characterization of Epidemic Cycles: COVID-19 Case Study</article-title>
          <source>JMIRx Med</source>
          <year>2021</year>
          <month>3</month>
          <day>18</day>
          <volume>2</volume>
          <issue>1</issue>
          <fpage>e22617</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://med.jmirx.org/2021/1/e22617/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/22617</pub-id>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
