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<?covid-19-tdm?>
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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMed</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id>
      <journal-title>JMIRx Med</journal-title>
      <issn pub-type="epub">2563-6316</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v1i1e24765</article-id>
      <article-id pub-id-type="pmid"/>
      <article-id pub-id-type="doi">10.2196/24765</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Peer-Review Report</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Peer-Review Report</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Peer Review of “A Machine Learning Explanation of the Pathogen-Immune Relationship of SARS-CoV-2 (COVID-19), and a Model to Predict Immunity and Therapeutic Opportunity: A Comparative Effectiveness Research Study”</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Eysenbach</surname>
            <given-names>Gunther</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Abbott</surname>
            <given-names>Eric</given-names>
          </name>
          <degrees>BASc EE, PEng, PE, MBA, MSEE</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Medical Health Informatics Graduate Program</institution>
            <institution>Northwestern University</institution>
            <addr-line>339 East Chicago Avenue</addr-line>
            <addr-line>Chicago, IL</addr-line>
            <country>United States</country>
            <phone>1 3125036950</phone>
            <email>abbottericb@gmail.com</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-0705-6712</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Medical Health Informatics Graduate Program</institution>
        <institution>Northwestern University</institution>
        <addr-line>Chicago, IL</addr-line>
        <country>United States</country>
      </aff>
      <pub-date pub-type="collection">
        <season>Jan-Dec</season>
        <year>2020</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>19</day>
        <month>10</month>
        <year>2020</year>
      </pub-date>
      <volume>1</volume>
      <issue>1</issue>
      <elocation-id>e24765</elocation-id>
      <history>
        <date date-type="received">
          <day>4</day>
          <month>10</month>
          <year>2020</year>
        </date>
        <date date-type="accepted">
          <day>4</day>
          <month>10</month>
          <year>2020</year>
        </date>
      </history>
      <copyright-statement>©Eric Abbott. Originally published in JMIRx Med (https://med.jmirx.org), 19.10.2020.</copyright-statement>
      <copyright-year>2020</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on https://med.jmirx.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://med.jmirx.org/2020/1/e24765/" xlink:type="simple"/>
      <related-article related-article-type="companion" id="preprint1-23582" ext-link-type="doi" xlink:href="https://doi.org/10.2196/preprints.23582" vol="1" page="e23582" xlink:title="Preprint" xlink:type="simple">https://preprints.jmir.org/preprint/23582</related-article>
      <related-article related-article-type="companion" id="v1i1e24739" ext-link-type="doi" xlink:href="10.2196/24739" vol="1" page="e24739" xlink:title="Author Responses to Peer-Review Reports" xlink:type="simple">https://med.jmirx.org/2020/1/e24739/</related-article>
      <related-article related-article-type="companion" id="v1i1e23582" ext-link-type="doi" xlink:href="10.2196/23582" vol="1" page="e23582" xlink:title="Published Article" xlink:type="simple">https://med.jmirx.org/2020/1/e23582/</related-article>
      <kwd-group>
        <kwd>infectious disease</kwd>
        <kwd>SARS-CoV-2</kwd>
        <kwd>COVID-19</kwd>
        <kwd>public health</kwd>
        <kwd>immunity: vaccinations</kwd>
        <kwd>therapeutics</kwd>
        <kwd>stem-cell growth factor-beta</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <p>
      <italic>This is a peer review submitted for the paper “A Machine Learning Explanation of the Pathogen-Immune Relationship of SARS-CoV-2 (COVID-19), and a Model to Predict Immunity and Therapeutic Opportunity: A Comparative Effectiveness Research Study.”</italic>
    </p>
    <sec>
      <title>General Comments</title>
      <p>This paper is excellent and very timely given its importance as it relates to supporting forthcoming mass vaccinations to address COVID-19 and potential prioritization of such vaccinations based on the study findings.</p>
    </sec>
    <sec>
      <title>Specific Comments</title>
      <sec>
        <title>Major Comments</title>
        <p>1. None</p>
        <p>2. None</p>
        <p>3. None</p>
      </sec>
      <sec>
        <title>Minor Comments</title>
        <p>4. Consider consistency of using COVID-19 vs SARS-CoV-2 (abstract vs text body).</p>
      </sec>
    </sec>
  </body>
  <back>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
  </back>
</article>
