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<?covid-19-tdm?>
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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMed</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIRx Med</journal-id>
      <journal-title>JMIRx Med</journal-title>
      <issn pub-type="epub">2563-6316</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v1i1e24747</article-id>
      <article-id pub-id-type="pmid"/>
      <article-id pub-id-type="doi">10.2196/24747</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Peer-Review Report</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Peer-Review Report</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Peer Review of “A Machine Learning Explanation of the Pathogen-Immune Relationship of SARS-CoV-2 (COVID-19), and a Model to Predict Immunity and Therapeutic Opportunity: A Comparative Effectiveness Research Study”</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Eysenbach</surname>
            <given-names>Gunther</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="no">
          <name name-style="western">
            <surname>Chang</surname>
            <given-names>Andy</given-names>
          </name>
          <degrees>BS, MS</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-0885-8725</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>School of Professional Studies</institution>
        <institution>Northwestern University</institution>
        <addr-line>Chicago, IL</addr-line>
        <country>United States</country>
      </aff>
      <pub-date pub-type="collection">
        <season>Jan-Dec</season>
        <year>2020</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>19</day>
        <month>10</month>
        <year>2020</year>
      </pub-date>
      <volume>1</volume>
      <issue>1</issue>
      <elocation-id>e24747</elocation-id>
      <history>
        <date date-type="received">
          <day>3</day>
          <month>10</month>
          <year>2020</year>
        </date>
        <date date-type="accepted">
          <day>3</day>
          <month>10</month>
          <year>2020</year>
        </date>
      </history>
      <copyright-statement>©Andy Chang. Originally published in JMIRx Med (https://med.jmirx.org), 19.10.2020.</copyright-statement>
      <copyright-year>2020</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the JMIRx Med, is properly cited. The complete bibliographic information, a link to the original publication on https://med.jmirx.org, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://med.jmirx.org/2020/1/e24747/" xlink:type="simple"/>
      <related-article related-article-type="companion" id="preprint1-23582" ext-link-type="doi" xlink:href="https://doi.org/10.2196/preprints.23582" vol="1" page="e23582" xlink:title="Preprint" xlink:type="simple">https://preprints.jmir.org/preprint/23582</related-article>
      <related-article related-article-type="companion" id="v1i1e24739" ext-link-type="doi" xlink:href="10.2196/24739" vol="1" page="e24739" xlink:title="Author Responses to Peer-Review Reports" xlink:type="simple">https://med.jmirx.org/2020/1/e24739/</related-article>
      <related-article related-article-type="companion" id="v1i1e23582" ext-link-type="doi" xlink:href="10.2196/23582" vol="1" page="e23582" xlink:title="Published Article" xlink:type="simple">https://med.jmirx.org/2020/1/e23582/</related-article>
      <kwd-group>
        <kwd>infectious disease</kwd>
        <kwd>SARS-CoV-2</kwd>
        <kwd>COVID-19</kwd>
        <kwd>public health</kwd>
        <kwd>immunity: vaccinations</kwd>
        <kwd>therapeutics</kwd>
        <kwd>stem-cell growth factor-beta</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <p>
      <italic>This is a peer review submitted for the paper “A Machine Learning Explanation of the Pathogen-Immune Relationship of SARS-CoV-2 (COVID-19), and a Model to Predict Immunity and Therapeutic Opportunity: A Comparative Effectiveness Research Study.”</italic>
    </p>
    <sec>
      <title>Comments for Authors/Editors</title>
      <p>Eric, very clear and concise paper. Very minor suggestions/clarifications/edits only on the abstract, none that I would consider to be substantive.</p>
      <list list-type="order">
        <list-item>
          <p>Stylistically, and I went back and forth on this multiple times as I did each of my reviews, the abstract almost reads like it was written by a different person. Your “main” paper flowed beautifully well in what I’ve come to expect from you: you set the stage, you provide the necessary background, you explain succinctly what you did, and then you go into discussions about the potential implications of the work. The abstract almost reads like separate bullets in a white paper, and I realize that you’re going up against wording or space constraints so in the big picture and with resource management, this isn’t one of those tasks or comments that rises to the top.</p>
        </list-item>
        <list-item>
          <p>In the conclusion portion of the abstract, do you think it would add value to call out or hat tip the following: (a) any of the limitations that you highlighted (maybe the top one or two?) and (b) the tie-in to economic and socioeconomic factors that you mentioned in the conclusion of the main paper? Again, I recognize that you may be going up against space and word constraints, so this may not be possible.</p>
        </list-item>
      </list>
    </sec>
  </body>
  <back>
    <app-group/>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
  </back>
</article>
